MuCO: Generative Peptide Cyclization

Enter a peptide sequence and explore backbone sampling, side-chain packing, and physics-aware relaxation in a single workflow.

Citation

MuCO: Generative Peptide Cyclization Empowered by Multi-stage Conformation Optimization

Yitian Wang, Fanmeng Wang, Angxiao Yue, Wentao Guo, Yaning Cui, Hongteng Xu

Start a MuCO run

Generate up to 3 backbone samples and 5 side-chain packings per backbone.

Peptide sequence

Length: 14/30 residues. Unsupported characters are ignored.

Backbone samples K: 1

Side-chain samples M: 1

Package successful relaxed structures as a ZIP

Generation Progress

Submit a sequence to begin.

Queue

jobs ahead in the queue

Stage 1 diffusion0/0

Stage 2 diffusion0/0

Stage 3 relaxed molecules0/0

Choose the Best Structure

Columns are backbone samples K; rows are side-chain packings M. Only successful relaxed structures are shown.

K1 / M1pending

No successful structure yet

Acknowledgments

MuCO builds on open scientific software for protein modeling, equivariant learning, and molecular simulation.